The results of the analysis of indicators of sleep questionnaire prior to treatment found that more than half of patients were expressed by sleep disorders, one third of the observations noted dissomnicheskie disorders and only one case had no complaints of poor sleep. Based on data from Beck questionnaire before treatment, 7 patients were found to self-light depression and 2 patients responded performance characteristics moderate depression. In other cases, there were isolated depressive symptoms. Baseline indicators Spielberger test demonstrated a high level of anxiety as "a moment" (srednegruppovoe value 59,9 ± 6,9 with fluctuations from 51 to 77), and "usually" (average for the group 57,1 ± 8,8 at spread from 38 to 75), which also is likely to correspond to pozdnevozrastnym characteristics of patients. Somatonevrologicheskoe condition of the patients studied group was characterized by a multiplicity inherent in later life pathology. On average, 1 patient had 3.5 diagnosis. Spectrum of diseases has also been characteristic of elderly and senile age. Table 1 shows the somatically patients before therapy Enerionom. Almost all patients received standard somatic therapy (antihypertensives, nitrates, antidiabetic drugs, thyroid hormones, calcium supplements, etc.) As indicated, 4 patients dropped out after 2-6 days the drug, so a statistical analysis of the effectiveness of therapy of asthenic disorders Enerionom was performed on 24 patients who completed the full course of treatment. To assess the statistical significance of changes in estimates used t-test. Analysis of changes in the indices of subjective fatigue scale (MFI-20) during treatment with Enerion showed the following (Fig. 1). Average score of the total fatigue decreased from 17,0 ± 1,8 to 15,0 ± 2,3, that is, the 2 values ??on day 7 of treatment and decreased to 11,6 ± 2,8, ie by 5,4 points, by the end of the 28-day course of therapy. The obtained differences were statistically significant on day 7 and day 28. Srednegruppovoy indicator "physical fatigue" has declined to 7 day from 15,3 ± 2,2 to 14,5 ± 2,5, ie by 1,9 points, not reaching the statistical significance of differences at this point the investigation, but at day 28 a decrease total score to 12,2 ± 2,4 ie by 5,9 points, reached a statistically significant value. On a scale of "reduced activity" srednegruppovoy score decreased from 14,8 ± 2,1 to 13,7 ± 2,4 to 7 day of treatment and up to 11,0 ± 2,8 at the end of therapy, showing a statistically significant difference in performance and on day 7 and on day 28. A fragment of the scale "to reduce the motivation" showed a slight and not statistically significant decrease srednegruppovogo points (respectively, 11.4, 11.3, 10.6). In terms of the scale "mental fatigue" statistically significant improvement in performance achieved by the end of the treatment period. Analysis of the marks made by patients to "line" visual analog scale, found a decrease in the values ??from baseline to 7,9 ± 1,0 7,5 ± 0,7 on day 7 and up to 4,6 ± 1,5 on day 28, and since 7 days, these differences were not statistically significant (Fig. 2).
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