Clinical researchers have ...

Researchers have clinical assessment of mental status, evaluation of vital functions (blood pressure, pulse rate) were recorded adverse effects in the scale of assessment of adverse symptoms. Dynamics of asthenic disorders rated on a scale of subjective assessment of fatigue (MFI-20), visual analog scale (VAS) fatigue. Studied the change of the questionnaire, vegetative changes, questionnaires assessing sleep, Beck depression questionnaire, as well as indicators of test anxiety, Spielberger. 24 patients completed the course treatment Enerionom. In 4 (14.3%) patients, the therapy was interrupted at the first week of treatment because of side effects. Clinically, the dynamics of asthenic disorders in the treatment of Enerionom determined primarily a decrease in severity of fatigue, increase endurance to physical and psychological stress, sometimes with a feeling "stay power" and confidence in meeting the target. In the subsequent observed recovery of activity and performance, habitual interests and employment in everyday life, significantly reduced the need for extra rest. Patients reported feeling "straightening" disappearance "oppressive" lethargy and weakness, talked about the desire to demonstrate to others the changes have taken place. Reduction of physical weakness, according to self-report of patients occurred in the first or most clearly detected by patients. Reduction of the signs of mental fatigue was also observed in an objective medical assessment. Along with improved mood and decreased expression of irritable weakness and emotional lability, the disappearance of tearful sensitivity markedly improved and clinical signs of cognitive functioning, increased ability to focus attention, thinking becomes more collected. Decreased expression of the general slowness of mental processes, improves the ability to switch attention and retrieval in the memory after distraction interventions. Prior to treatment asthenic disorders in clinical evaluation and on a scale of MFI-20 proved to be quite pronounced - with fluctuations of overall fatigue from 14 to 20, averaging 17 ± 1,8 points. In this case, dominated by patients with severe physical asthenia (srednegruppovoy index 15,3 ± 2,2 with fluctuations from 13 to 20) and reduced activity (average of 14,8 ± 2,1 with fluctuations from 12 to 20). Dial average estimate reductions motivation was 11,4 ± 2,2 (varying from 6 to 16). A similar situation was registered in the subjective evaluation of mental fatigue (srednegruppovoy index 11,4 ± 3,3 with a range from 5 to 20). Srednegruppovoy measure fatigue severity on VAS before starting Eneriona was 7,95 ± 0,98, reflecting the severity of asthenic disorders on the basis of subjective evaluation by patients. Filling the questionnaire vegetative changes revealed extremely high levels in virtually all patients, on average three times higher than the threshold level (average of 44,1 ± 8,5 with a range from 31 to 60), which may reflect the age composition of patients with typical late age abundance of somatic complaints.