Thus, it became clear that there is ...

So, it became clear that there piridoksinzavisimaya form of epilepsy, in which the appointment of vitamin B6 produces a certain therapeutic effect [49]. At first, it would seem disappointing use of ketogenic diet again turned the focus of researchers in recent years. Despite the emergence of new anticonvulsants, ketogenic diet was once widely used, especially in severe, refractory epilepsy in children [50.51]. According to a recent UK survey of doctors, nutritionists, children's clinics for treatment of epilepsy ketogenic diet is used in 17% of the hospitals, and in addition to its traditional form (4 parts oil, 1 part protein, 1 portion of carbohydrate), many patients are assigned separately from the content of fat 60% medium chain triglyceride [52]. Currently, pediatricians recognized that, in spite of contradictory information and lack of mechanism of action, The ketogenic diet is effective in children with epilepsy resistant to therapy [53.54]. The use of ketogenic diet (4:1:1) with fluid restriction in adult patients (19-45 years) also showed its significant efficacy, as in generalized seizures, and in partial form [55]. Attention to such non-traditional (dietary) therapies are attractive not only resistant to drug therapy forms of epilepsy. With long-term treatment of epilepsy, anticonvulsants revealed negative effects of these drugs - the metabolism of vitamin B12 and folic acid (with no signs of anemia). As a consequence, may develop schizophrenia-like psychotic conditions that aggravate the disease and often leads to errors in diagnosis and treatment, particularly in elderly patients [53.56]. These side effects may be to some extent alleviate the special diet. In addition, it is revealed that the majority of anticonvulsants increases in blood levels of homocysteine ??- sulfur-containing amino acids, which may explain the teratogenic effects of these drugs [57], and that can also be corrected by dietary interventions. Being effective enough (especially in patients with severe, refractory to drug therapy for a form of epilepsy), ketogenic diet requires a careful study of all substances entering the body, including drugs. The first analyzed the carbohydrate content (not just regular sugar, but also other components such as starch). The presence of carbohydrates, even in farmakopreparatah can reduce the effect of ketogenic diets suppress ketosis [58]. Animal studies using various types of "fat" diet (medium chain triglyceride, lard, linseed oil and butter, etc.), showed that the anticonvulsant action of ketogenic diet depends not only on the values ??of indicators of the level of ketosis, but on its duration and stability of [ 59]. Considerable attention is now paid to the development of special diets for the treatment of schizophrenia. Back in the 70-ies of XX century researchers have hypothesized about the pathogenetic role of gluten (vegetable protein, which is part of many grains) and casein (the protein that forms the basis of milk) in the development of schizophrenia [60].