The presence of a definite connection backed up by ...

The presence of a definite connection backed up by laboratory data - in particular, in patients with schizophrenia compared to control was detected increase in antibody titers of immunoglobulin A class in response to gliadin, beta-lactoglobulin and casein [61]. Later it was revealed that some peptides derived from enzymatic hydrolysis, possess a high degree of opioid activity [62]. These results enabled FCDohan (1988) put forward a hypothesis about the genesis of schizophrenia in combination of two factors: the genetic abnormalities that contribute to increased permeability of cell membranes, on the one hand, and a diet containing gluten and casein, on the other. The totality of these conditions, according to this theory, leads to excessive accumulation of ekzorfinov in CSF, which may clinically manifest symptoms of schizophrenia, autism [63.64]. At the moment the attention of the scientific world is riveted to the study of beta-kazomorfina (beta kazorfinu), a group of opioid peptides, isolated from beta-casein female, cow and goat milk, and studies have shown that participating in the formation of psychological connection, according to the "mother - child "playing the role of a" food hormones ". However, while the assumption that the pathological effects ekzorfinov per person is not completely prove or disprove, and research in this area continues [65-67]. During the development and practical application of special "antishizofrenicheskih" (free of gluten and casein) diets by clinicians at different times, were received too inconsistent data, which, although not allowed to date, reliable evidence of the therapeutic efficacy of this method [64,66,68 -73], but, nevertheless, emphasize the importance of further research. The role of casein in the pathogenesis of schizophrenia is getting back in the last few years dealing with issues of feeding infants. Breast milk contains a much smaller amount of casein compared with artificial mixtures of substitute products. This led me to think about the pathogen (in terms of later development of schizophrenia) Influence of artificial feeding. Retrospectively studied the eating habits of patients with schizophrenia in the first year of life. The results of these studies to date has also not given a clear answer to the question of the pathogenetic patterns of involvement of casein in the development of schizophrenia [74.75]; clarify the correctness of this concept appear in the nearest future. Increasing production and consumption of dairy products by the population of all countries makes researchers more in-depth approach to studying the chemical composition of milk and the processes involved in its metabolism as a result of incomplete cleavage of milk protein in the body formed by a number of intermediate bioactive compounds that are able, as expected, with penetration the internal environment to cause various changes not only in physiological processes, but even in a number of psychological functions, including adults.