The frequency of these violations is sufficient ...

The frequency of these disorders is quite high, according to different authors, 1020% in the population [7]. It should be noted that adequate therapy of these disorders is of great social significance. For example, several studies have shown that patients who suffer permanent or paroxysmal psychovegetative disorders have higher cholesterol levels, twice the risk of stroke, significantly the risk of hypertension, myocardial infarction, compared with the general population [5,12]. Comparative analysis of the risk of suicide has shown that it is 20% for people with psycho-vegetative disorders, and about 6% for patients with other mental disorders [7]. Particularly frequent suicidal tendencies can be traced in patients who have a sense of irritation and anxiety coupled with episodic panic attacks in patients with long-existing psycho-vegetative disorders, in particular, the transformation in anxious depression. Another equally important social factor is the increased risk of using alcohol and benzodiazepines, as well as the abuse of these substances with the syndrome of psycho-vegetative disorders. Thus, the constant use of alcohol in these patients was 24.3%, dependence occurs in 8.7% of patients who abuse benzodiazepines observed in approximately 26% of patients, other narcotic drugs in 17% of patients [10]. Factors that lead to the development of psycho-vegetative disorders, to date not fully understood. Sure, certain personality traits are important. The possible role of adrenergic regulation violations. It is known that locus coeruleus, as one of the suprasegmental structures of the autonomic regulation of afferent and efferent projected on a large number of the brain, creating an extensive network of behavioral and autonomic regulation. Experimental data show that anxiety disorders, in particular, may be due to sympathetic hyperactivity. Indirectly, this also confirms the fact that patients with psycho-vegetative disorders marked decrease in the number of presynaptic a2adrenoretseptorov that can be explained by the inclusion of protective, anskioliticheskih mechanisms. [9]. During the research it was assumed that psihovetetativnye disorders may develop as a result of genetic transforming adrenoceptor blockers and the emergence of a population with an altered sensitivity [11]. Unfortunately, multiple studies have not confirmed this hypothesis. Significant role in the development of psycho-vegetative disorders is given to reduce g-aminobutyric acid (GABA), which is one of the major inhibitory neurotransmitters of the brain (Fig. 1). It is known that GABA is metabolized to glutamate (this is possible both the direct and reverse reaction), followed by glutamate under the action of glutamate is split to the level aketoglutarovoy acid.