For physiological conditions typical of ...

For physiological conditions typical of the reverse reaction, ie formation of glutamate and GABA further. It is assumed that patients with psihovegegativnymi disorders may be a special form of glutamate, which gives a direct physiological conditions, the reaction that leads to the accumulation of glutamate and reduced formation of GABA. Additional role in the formation of these violations may play a reduced sensitivity of benzodiazepine receptors and modify their ability to bind to the relevant mediators [10]. Fig. 1. Metabolism of g-aminobutyric acid in patients with psycho-vegetative disorders mediator violations in psycho-vegetative disorders can be broadly represented in different brain regions, with the prevalence of anxiety disorders may result from dysfunction of mainly the limbic system. Paroxysms psychovegetative disorders may be due to changes in the regulatory influence of the reticular formation and its connection with other entities suprasegmental autonomic regulation. Phobias tend to have a more complex formation mechanism. Genesis of the phobia related, including the formation of behavior change and changing perceptions. Thus, in this case we can talk about the interest of the cerebral cortex of the brain [9]. It should be noted that the peripheral autonomic system can not only serve as a mechanism to implement clinical manifestations psihovetetativnyh disorders, but also to participate independently in their formation. So, now discuss the possible participation metasympathetic system in the development of psycho-vegetative syndrome. In particular, we show that the introduction of cholecystokinin increases the level of anxiety not only in patients with psihovegegativnymi violations, but also in healthy subjects [9]. These changes may be due to a competitive interaction of this mediator with the benzodiazepine receptors and direct stimulation metasympathetic system. In this case, the primary manifestations of anxiety can be realized at the peripheral level. Only with long-term existence of anxiety disorders in the pathological process may involve central mechanisms. Based on the proposed pathogenesis of psycho-vegetative disorders, it is obvious that the main place in the treatment of these disorders play a derivative of benzodiazepine tranquilizers [4]. Currently, we have to admit that this method of treatment is far from ideal, primarily because of developing side effects. The most frequent side effects include increased sleepiness, decreased attention span, poor coordination. Given the fact that psycho-vegetative syndrome develops mostly in working people, obviously the effect of this therapy on patients experience. Often, developing impaired function in patients receiving benzodiazepines may lead to social maladjustment of patients.