Treatment Pirazidolom usually ...

Pirazidolom Treatment is usually not accompanied by the development of clinically significant adverse effects, or they are very rare in comparison with the encountered when using tricyclic antidepressants and irreversible MAO inhibitors [7]. Do not usually experience orthostatic hypotension and cardiac arrhythmias. Not marked characteristic of some antidepressants deviation in sexual sphere. Holinoliticheskie such effects as drowsiness and sedation are found very rarely. At the same time the appointment Pirazidola does not usually lead to the enhancement or development of insomnia and agitation, rarely causes gastrointestinal symptoms. Pirazidol incompatible with other MAO inhibitors, including drugs with similar activity (furazolidone, procarbazine, selegiline). Regarding the latter, these drugs should especially bear this in mind, since selegiline is widely assigned in neurological practice for the treatment of diseases in which parts of depressive disorders (Parkinson's disease, mild dementia of vascular origin, and atrophic). In a joint application with Pirazidola adrenomimetikami and products containing tyramine, may increase pressor effect. Desirable to simultaneously receive Pirazidol and thyroid hormones: Also due to the risk of hypertension. Adverse drug interactions Pirazidola and cimetidine, as this slows down the metabolism Pirazidola, worse in this regard, its main effect and increases the risk of side effects. Pirazidol has the ability to increase the effects of analgesics. Can not be combined with dextromethorphan Pirazidol because of possible toxic reactions of the CNS [5]. Combined application Pirazidola concurrently with tricyclic antidepressants and selective serotonin reuptake inhibitors is not recommended, as it may cause symptoms of serotonergic overactivity (hyperthermia, confusion, hyperreflexia, myoclonus). But they allowed the appointment immediately after the abolition of Pirazidola. Of particular interest is the combination of Pirazidola with nootropics and tranquilizers. Established that piracetam enhances the action Pirazidola, as well as other antidepressants. This can make a difference in the tactics of treatment of depression, aimed at overcoming the therapeutic resistance or decrease in therapeutic doses in poor tolerability. When combined with diazepam Pirazidola weaker sedative effect of diazepam without decreasing its anxiolytic effect, and the anticonvulsant properties of diazepam even worse. This interaction Pirazidola with diazepam can be used to reduce the side effects of benzodiazepines. Thus, a successful past experience in the application of domestic anti-depressant Pirazidola reproduced in recent studies, which confirms the need for its use in the treatment of a wide range of depression in general psychiatry and somatic medicine.