Treatment of common ...

Treating these common disorders are engaged and psychiatrists, and internists. Appointment Pirazidola rightly and brings the greatest effect in diffuse, not well designed or polymorphic depressive syndromes, as well as unstable states with the vibrations of the depth and variability of the structural components of depression [8]. In pursuit of the current research psychopharmacological activity Pirazidola evaluated from the standpoint of the concept of positive and negative affectivity. It is shown that the treatment of non-psychotic depression level [2] Pirazidol detects significantly more effective in depression with a predominance of positive affectivity. Among the responders were patients with depression, leading to the manifestations of which were vital, disturbing and senesto-hypochondriacal symptoms. Apatoadinamicheskie and depersonalization depression, ie depression and negative affectivity, enachitelno worse respond to treatment Pirazidolom. The overall effectiveness of therapy was 73%. Noted that the drug exhibits equal strength stimulating and sedative effects, and regression of the symptoms of anxiety ahead of the positive dynamics of the actual gipotimii. In addition to using the drug in General Psychiatry, showed that Pirazidol can be successfully used for the relief of mood disorders that accompany most diverse pathology of internal organs. Vegetostabiliziruyuschee effect of the drug can be used in the treatment of autonomic and somatized depression. Recommended the appointment of Pirazidola for treatment of depression in patients with chronic pain syndrome, in particular, lumbosacral localization [15]. Proven good tolerability in the case of a combination of psychic and somatic pathology and the possibility of combination with basic therapy. As shown in a recent study of therapeutic effect Pirazodola the treatment of depressive disorders in patients with coronary heart disease (3), the drug has no "cardiotoxicity," has no effect on blood pressure, heart rate, does not cause orthostatic hypotension and exhibits protective properties under conditions of tissue hypoxia due to circulatory disorders. Noted that Pirazidol not become clinically significant interaction with the major cardiotropic means that used in the treatment of coronary artery disease. Detection in the experiment neuroprotective, antioxidant properties Pirazidola under hypoxic conditions, including circulatory, opens up prospects for studying the application of the antidepressant as a corrector of cognitive dysfunction [8]. It seems perfectly justifiable purpose Pirazidola as an antidepressant of first choice for the treatment of depressive states, which are increasingly identified in the initial stages of dementia of late life. Of considerable importance is also the fact that practically no drug holinoliticheskie effects typical of many antidepressants and highly undesirable due to increased cognitive impairment in the existing shortage of acetylcholine in elderly patients with dementia.