Findings from research ...

The results of research carried out by comparing the antidepressant properties Pirazodola with the clinical effects of other well-known antidepressant, showed a significant peculiarity of this drug. In these studies, [6,9,10] asserts the undoubted effectiveness Pirazidola for depressive symptoms, rather fast onset of therapeutic effect and high safety. Unanimously acknowledged a wide range of therapeutic effects of the drug on the manifestations of depression, in connection with which Pirazidol drug called "universal", "balanced" action. Found a clear impact Pirazidola on various components of a depressive syndrome, while identified as a proper timoanalepticheskoe action, and activating at the same time with a distinct anxiolytic effect. The intensity of these individual manifestations of antidepressant drug activity was estimated by the authors the first studies in different ways. Pirazidol not exceed the first-generation antidepressants in power timoanalepticheskogo exposure and even inferior to them in this, but discovers at the same time certain advantages due to the fact that did not cause exacerbation of psychotic symptoms, excited and reversal of affect. Activating effect Pirazidola characterized by gentle impact on the symptoms of lethargy and adinamii, did not lead to increased anxiety, agitation or tension. The most interesting feature of antidepressant action Pirazidola was a combination of activating and simultaneously protivotrevozhnogo effect without gipersedatsii, drowsiness and increased inhibition, which is known to be characteristic of tricyclic antidepressants. Marked absence of a sharp dissociation between activating and anxiolytic action Pirazidola conditioned harmonious therapeutic effect on symptoms of depression. Already at the beginning of clinical studies of the drug was observed to dose-dependent effect. Using Pirazidola in small and medium doses (75-125 mg) Identify more clearly its stimulative effect, with increasing doses (up to 200 mg and above) was more evident protivotrevozhny component of antidepressant action Pirazidola. If necessary, combination therapy along with Pirazidolom administered antipsychotics, tranquilizers and anticonvulsants, mood stabilizers. Involuntary absence Pirazidola for many years in the arsenal of treatments for depression has been very noticeable. Despite the emergence of effective and safe to use antidepressants new generations an adequate substitute for the drug has not appeared virtually. Return Pirazidola into clinical practice has confirmed its relevance and ability to compete with the new antidepressants due to lack of practical cholinolytic side effects, relatively high efficiency and availability of acquisition. From the perspective of the clinician facing the choice of an antidepressant in a particular clinical situation, it is important that Pirazidol has its therapeutic niche, whose boundaries have expanded due to the fact that they became more prevalent depression, mild to moderate severity with an atypical pattern and prevalence of anxiety hypochondriacal disturbances in their structure.