Considering the continuum of obligate ...

Considering the continuum of obligate asthenic disorders (Fig. 1), we should pay attention to the extremes of this spectrum. At one of these - fatigue, due to mental and physical diseases organically, and is characterized by a low reversibility (organic asthenia, asthenic defect autochthonous asthenia, asthenic constitution, asthenic personality development). As we move to the other end of the spectrum increases polymorphism and reversibility of asthenic conditions that act at somatic diseases in the exogenous-organic reactions (similar to the reactions of exogenous Bonhoeffer) or psychiatric disorders - in asthenic neurosis (neurasthenia). Multifactorial mechanisms of asthenic conditions predetermine the plurality of therapeutic intervention, including the full range of psychotropic drugs. This is probably due to the lack of clear understanding of the neurobiological mechanisms of pathogenesis of asthenia (for example, in contrast to depression, schizophrenia). Moreover, "ordinary" and too prevalent complaints of such patients often leads them to resort to self-treatment. Thus, internet-based search revealed Therapy of asthenic disorders is one of the most popular to the public. The spectrum of drugs on these websites is extremely wide: from vitamins to anti-depressants. Evidence-based recommendations for treatment of most asthenic conditions include the appointment of psychostimulants and nootropics. Despite the fact that stimulants are that a group of psychotropic drugs, the main indications for which were asthenic disorders, their use in these cases is highly undesirable. The phenomenon of withdrawal, the development of dependence and abuse, the risk of physical complications, and many other adverse reactions occur in the treatment of this group of psychotropic drugs frequently and quickly. An alternative is the use of psychostimulants for the treatment of asthenic states neurometabolic drug action in psychopharmacological spectrum which revealed a distinct awareness inducing effect. Such preparations have the properties of psychostimulants (increased psychomotor activity), and nootropics (improvement of cognitive functions) and can be separated into a special group antiastenicheskih funds. These drugs do not have nezhelatelnymieffektami psychostimulants (complications and contraindications of their use, etc.) and also have the possibility of wider application than the nootropics, whose effect is primarily manifested in the treatment of organically caused by fatigue. Designation antiastenicheskih drugs as a special class of psychotropic drugs is dictated not only the peculiarities of their action and use, but it is important in the sense of raising the profile of the problem of therapy is so common in clinical practice asthenic states. Such drugs include deanola atseglumat, salbutiamin, idebenone and a new domestic preparation Fenotropil having along with the properties of nootropics pronounced stimulating effect.