For the left hemisphere strokes characteristically ...

For the left hemisphere strokes characteristic of the subsequent development of GAD and depression, while right-brain - mainly GAD [9.16]. The defeat of the basal ganglia accompanied by the development of depression only, and the combination of basal and cortical foci of cerebral blood flow leads to the development of depression and GAD [82]. Leppavuori et al. [58], surveying 277 stroke patients with primary and post-stroke with GAD, found that the social functioning of patients with post-stroke GAD was significantly worse than the primary. GAD is the most common of mental disorders (44,7%) in patients with tension headaches, depression, while the second frequency-place (36,8%) [68]. In patients with migraine prevalence of GAD is 10% [34], patients with a sheaf headaches - 14% [40], significantly exceeding the one in the population. In gastroenterological practice has long been known combination of peptic ulcer with increased anxiety [65]. Shown that increased anxiety is the only baseline characteristics to predict poor healing of the ulcer in the course of therapy [59]. In the National Comorbidity survey (8000 surveyed) the presence of GAD increased the risk of peptic ulcer in 2,2 times, while the number of symptoms of GAD is mainly correlated with the presence of peptic ulcer disease. It is known that, although H. pylori is found in almost all patients with peptic ulcer disease, only a small percentage of carriers suffer from peptic ulcer disease. We can assume that a state of chronic stress, which is characteristic of GAD, alters the immune response, a shift of inflammatory reactions at the micro-organisms that normally are controlled by Th1-lymphocytes, cytokines (including H. pylori). In this study, was identified and an inverse relationship: peptic ulcer disease was the only physical illness, increasing the risk of GAD (2,8 times). Perhaps here there is no causal link, and general predisposing factors (eg, genetic) or environmental factors [31]. Up to 40% of patients with irritable bowel syndrome (IBS) have GAD, and vice versa - to 50-88% of patients with GAD suffer from IBS [62]. The presence of GAD significantly worse results of treatment of IBS. According to some reports, in the early stages of IBS dominates anxiety, and at later - depression. Pathogenetic link between increased anxiety and altered bowel motility numerous; obviously important role is played by the central noradrenergic system and corticoliberin [11]. Cases of anxiety disorders are described in most endocrine diseases [35], but systematic studies are carried out mainly by the combination of GAD with thyroid disease and diabetes. Current prevalence of thyroid disease in GAD is not higher than in the population, but in the history of the frequency of thyroid disease in patients with GAD was significantly increased (10%) [79]. In diabetes the prevalence of GAD ranging from 14% to 40% [33.61].