The effect increases as the continuation of treatment. Zoloft is used to treat all types of depression of varying severity. Sertraline has a positive effect in patients with anxious depression and sleep disorders, anxiety reduction is much faster than with fluoxetine. In the case of a mixed-anksiozno melancholy affect vital manifestations are reduced in parallel, followed by normal mood, there is an increase of mental activity, suicidal thoughts disappear and somatoform disorders. In small doses (100 mg / day) drug is used prophylactically in recurrent depression. Furthermore, sertraline is used to treat obsessive-phobic disorders. In these cases, the best effect is achieved with the appointment of 150-200 mg / day for 8-12 weeks. Since the half-life of the drug is about one day, he applied in a single dose - 50-200 mg / day (minimum and optimum dose - 50 mg). If necessary, increase the dose of 50 mg / day 1 day a week. For preventive purposes it suffices to 50-100 mg per day. Zoloft is effective and safe for all ages: children, adults and elderly patients. The uniqueness of the drug is that the individual selection of doses, depending on age, is not required. The drug does not increase the influence of alcohol, carbamazepine, haloperidol on cognitive and psychomotor function, while the reception. Sertraline does not cause sedation and has no effect on psychomotor function, is not addictive, does not have cardiotoxic effects, well tolerated by patients with cardiovascular diseases. Proved high efficacy for obsessive-compulsive and panic disorders, generalized anxiety. With prolonged use Zoloft does not increase tolerance and become addicted. The wide use of Zoloft to treat depression caused by: high efficiency (an antidepressant effect comparable with that of classical antidepressants) was well tolerated in combination with the low number of side effects, soft, balanced action, uniform effect on all components of depressive affect (anxiety, depression, apathy ) effect on anxiety-depressive, depressive, phobic and depressive-hypochondriacal condition; ease of use (once a day, there is no need for selection of optimal dose), the absence of marked sedation, which allows to keep the rhythm of life and social activity. For second-line drugs classified traditional timoanaleptiki - monoamine oxidase inhibitors - MAOI (their use in modern psychiatric practice due to the high toxicity is extremely limited) and tricyclic antidepressants - tricyclics. Medicines of this series have a pronounced psychotropic effect, shown for use in psychiatric institutions, where the ratio of risk-benefit "of treatment in relation to the severity of depression is shifted in favor of intensive therapy.
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