Possibilities of therapy of depression ...

Opportunities treatment of depression in general practice enhanced by the identification of citalopram (and other SSRIs) actually somatoreguliruyuschego action. Feature of this effect of citalopram - Antinociceptive effect of chronic pain disorder associated with both depressive affect, and independent of it. Along with a high therapeutic index (safety in overdose) Citalopram is characterized by chronic administration of security, favorable pharmacological and pharmacokinetic interactions, optimal portability. Citalopram is not conducive to a change in appetite and weight. Citalopram is easy to use: taking 1 per day at any time, regardless of the meal. The starting and maintenance dose - 20 mg / day. Does not interact with alcohol. Thus, citalopram - the most selective serotonin reuptake inhibitor. He does not interact with other mediator systems, causes the least side effects. Equally highly effective in depression of any cause, severity and structure. Equally citalopram affects the whole spectrum of depressive conditions: anxiety, apathy, adynamic, melancholy, melancholic, and others have a minimum of interactions (interactions mezhlekarstvennyh) c other drugs, including in the treatment of comorbid depression in somatic patients. Compatible with analgesics, antihistamines, antihypertensives, including beta-blockers and other cardiotropic means. Does not cause drug dependence. Citalopram in the treatment of virtually no recorded withdrawal syndrome. Has tolerability and safety of the elderly. Significantly reduces the frequency of recurrent depression with a long reception. Modern therapeutic approach is determined by the principle of efficiency (overall effectiveness, especially the spectrum of action, time of onset of clinical effect, prophylactic efficacy) and safety principles of treatment. In this respect, citalopram in comparison with other SSRIs and antidepressants reference has several advantages. Article published in Pharmaceutical Journal

The synergy effects of antidepressants "double" of the

Avedisova Alla S. Doct. med. Sc., head of new drugs and therapies Federal Research Center for Social and Forensic Psychiatry. VPSerbsky Federal Agency for Health and Social Development "in recent years in the treatment of depression was a change of views on the criteria of the effectiveness of therapy and related this way to achieve it. This was largely due to the advent of new drugs with antidepressant activity. Strategy for the discovery of these drugs has changed dramatically: to replace the concept of "selectivity" came the concept of "complex" effects, accompanied by the appearance of drugs "double" action. Such a trend can be seen in pharmacology as a whole (the appearance of drugs "double" action among antigipertonicheskih, antiepileptic drugs, etc.).