After a two-week period wash-out ...

After a two-week period of wash-out baseline survey was conducted of patients, which included clinical neurological examinations, questionnaires, psychological testing and research of cognitive evoked potentials P300 by Odd-ball paradigm that characterizes the level of memory and focused attention [2]. Clinical and neurological methods included detailed anamnestic data collection using standardized questionnaires ballirovannyh to assess the state of the autonomic nervous system, being under the visual analogue scale (VAS), fatigue and sleep quality questionnaire [1]. State mental sphere was assessed with Spielberger's test (for the definition of reactive and personal anxiety) and test Beck's (evaluation of depressive manifestations) [7,10,14]. Also studied short-term memory (visual memory of figures and images, mediated memorization), concentration and performance (Bourdon test, table Schulte) [3,5]. Patients were prescribed monotherapy Enerion 2 tablets per day (400 mg salbutiamina) within 28 days. The second examination was performed on the 7 th and 28 th day of therapy. Cognitive function was assessed before treatment and after treatment. The results are shown in Tables 1 and 2. We surveyed our patients, in addition to complaints of general weakness (100%), fatigue (100%), feeling of constant fatigue (100%), decreased performance (90%) and concentration (80%), memory impairment (50%) difficulty learning new information (47%) were identified nonspecific complaints of increased anxiety (75%), feeling of constant internal pressure (62,5%), reduction of background mood (65%), lower self-esteem (55%), anorexia ( 65%), headaches meeting the criteria of tension headaches (55%), sleep disturbance (55%), dizziness (48%), palpitations (45%), pain in the left half of the chest, not related to physical load ( 40%), gipotimicheskie state (35%), feeling short of breath (27.5%). The therapy was significantly regressed such clinical symptoms as general weakness (30%), fatigue (30%), decreased efficiency (27,5%), emotional lability (25%), feeling of inner tension (27%), increased anxiety (17%), pain in the heart (25%), headache (27%), sleep disturbance (20%), difficulty concentrating (19%), memory impairment (20%). Duration of disease ranged from 1 to 24.5 months (mean duration of 12,2 ± 4,8 months). Among the factors that encourage the development of asthenic syndrome, should be identified: long-term stressful situations, 75%, work seven days a week and leave 50%, acute traumatic situation 25%, heavy physical work 10%, concomitant somatic diseases 10%, 50% of patients had a combination of two or more predisposing factors. According to the questionnaire testing of patients before treatment had a pronounced asthenic manifestations (high rates of fatigue questionnaire), anxiety disorders (increased rates of reactive and personal anxiety on Spielberger test), significant autonomic dysfunction (according to surveys of vegetative disorders), sleep disorders (according to questionnaires subjective assessment of sleep), mild depression (Beck, under the test), poor health (by visual analog scale).