A number of studies have shown that ...

A number of studies have shown that exacerbation of paranoid schizophrenia is accompanied by an increase in the intensity of lipid peroxidation and reduced antioxidant protection. At the same time in parallel and detected irregularities in the structure of erythrocyte membranes, increasing the metabolism of phospholipids, so that there was an assumption about the possibility of a certain therapeutic effect when using omega-3 fatty acids (eg linolenic acid) as a dietary supplement to neuroleptic therapy [88-90]. Clinical data on the positive effects of omega-3 fatty acids on cognitive function in the elderly have been published in a recent study of B. Heude et al. (2003) [91]. Among the many researchers enjoyed a growing interest in the issue of drug-food interactions in psychiatry. One of the most studied effects of this kind is part of tyramine (a substance that leads to the formation of histamine) in the pathogenesis of hypertensive (giperadrenergicheskogo) crisis, the specific complications of the use of antidepressants - monoamine oxidase inhibitors (MAOIs). The danger of such a serious complication limits the use of these potent drugs in psychiatry, and in case of their appointment requires strict dietary precautions. In patients receiving MAOI banned a number of products with high content of aromatic amino acids (tyrosine, phenylalanine, tryptophan and histidine) - meats, cheeses, sausages, yogurt, sour cream, coffee, chocolate, yeast, beans, beer, red wine, canned figs, bananas, avocado, beef and chicken liver - which can (even if they are good quality, and especially - in the long-term storage, contamination or deterioration), to accumulate tyramine and histamine [32,33,92-94], and therefore absolutely contraindicated in the treatment of MAOI. Clozapine (azaleptin, leponeks) and caffeine are competitive substrates of the same enzyme CYP1A2. Experiment to eliminate caffeine from the diet of patients with schizophrenia has led to marked changes in the metabolism of clozapine, on the basis of which recommendations were made to control the consumption of caffeine, patients receiving clozapine [95]. Sodium and caffeine increases the excretion of lithium in urine. Cases of lithium toxicity in patients complying with a salt-free diet, as well as the sudden cessation of their consumption of coffee, which justifies the need for nutritional caution in patients receiving long-term lithium [30-32,92]. Summarizing, we can conclude that dietitians (and, more broadly, nutritionist) can and should play a significant role as part of an interdisciplinary medical teams to treat mentally ill patients [33.96]. Although raised in the review questions and links threpsology Psychiatry and do not cover the breadth of the problem, however, they indicate the growing interest of world medical science and practice of promising and promising interaction of these disciplines. Literature Shevchenko YL The concept of Quality of Life Research in health care. / / Med.gazeta, 2000. -N.53-54.-C.6-7.