Moreover, as shown in our ...

Moreover, as shown in our studies, the insomnia itself is not for most people (both healthy and suffering from insomnia), the priority factor in the hierarchy of their perceptions of health, including mental. Great value for them is being in the daytime and its deterioration under the influence of sleeping pills. Quality of awakening is reflected in psychophysiological functioning of the presence or absence of fatigue, sleepiness, poor coordination, etc. The physical well-being assessed at different times of day: morning, noon, mid-day, 1718 hours and evenings. Compared with barbiturates and benzodiazepines use hypnotics of third generation to a lesser extent accompanied by a violation of daytime functioning, memory functions and attention, psychomotor speed of reaction, vigilance (the so-called phenomenon of aftereffect). One of the qualitative assessment of the hypnotic is its influence on the architecture of sleep. Modern hypnotics also reveal an advantage for this indicator. Unlike barbiturates, which are pruned and 1,3,4 REMstadii sleep, and benzodiazepines, increase the 2 stages and decrease the 3 and 4 sleep stages, the use of hypnotics of third generation is accompanied by the restoration of the physiological structure of healthy sleep. The least known of the factors affecting the quality of sleep is the circadian rhythm sonbodrstvovanie is seen as a fundamental property of living organisms in the formation of which the leading role belongs to endogenous mechanisms. The need to integrate Biorhythmological type of person when selecting a hypnotic reflects the general features of pharmacotherapy, allowing use конституциональнобиологические human characteristics (eg, Biorhythmological type) as the criterion for its adaptation, including drug resistance. We carried out a comparative analysis of results of treatment of insomnia hypnotics of different generations, depending on the type of person Biorhythmological showed that the improvement of quality indicators of sleep medication in the treatment of third-generation occurs in the recovery of its basic parameters within the limits inherent in the rules for determining Biorhythmological type, which is an indicator of improvement sleep quality. Significant differences between the three generations of hypnotics are identified in the assessment of tolerability and safety. The greatest difficulties arise in the application of severe barbiturate sedation, impaired coordination, increased body weight, skin rashes, suppression of respiratory function, the effect on heart rate, blood pressure, body temperature, high risk for drug interactions, congenital defects, and hemorrhagic disease in newborns (penetration through the placenta and in mother's milk), lethality in megadoses, etc. The use of other hypnotics first generation is also associated with a fairly high risk of poor coordination, sedation, anticholinergic effects, renal dysfunction, paradoxical effects of CNS, with the possibility of provoking seizures in patients with organic brain , teratotoksichnostyu in high doses, excretion in breast milk (antihistamines), or with significant limitations of hepatic, renal, cardiac pathology, gastritis, peptic ulcer, respiratory failure (chloral hydrate).