This can be corrected by giving ...

This can be corrected by assigning timoizolepticheskie and antiepileptic drugs in the following conditions. Organic personality disorder: labile, disinhibition, aggressive type. Organic affective disorder: manic, depressive, distimicheskoe. Organic anxiety disorder. Anxiety and phobic disorders: agoraphobia, panic disorder, generalized anxiety disorder. Symptomatic disorders in patients with signs of organic dysontogenesis: enuresis, encopresis, stereotyped movement disorders, stuttering, transient tic disorder. Paroxysmal abnormal attraction to epileptiform activity: alcoholism; pyromania; dromomaniya; kleptomania. Bipolar affective disorder. Recurrent depressive disorder. Cyclothymia. Anticonvulsants have not only timoizolepticheskim effect, but also antinociceptive. Carbamazepine is indicated for chronic somatoform pain disorder (psychogenic back pain, psychogenic headache, and others), and neuralgias (trigeminal neuralgia, idiopathic glossopharyngeal neuralgia, pain in diabetic neuropathy, paresthesia, and paroxysmal attacks of pain). On mechanism of all known anticonvulsant drugs can be classified into four main groups: operating primarily by inhibiting the release of excitatory neurotransmitters by the blockade of sodium channels (phenytoin, carbamazepine, lamotrigine), acting mainly by enhancing GABA-ergic transmission (benzodiazepines, barbiturates, vigabatrin, gabapentin , Tiagabine); stabilizing thalamic neurons by inhibiting calcium channels of T-type (Ethosuximidum) have an effect through a combination of these mechanisms (valproic acid, felbamate, topiromat, zonizamid). Pharmacological properties of various anticonvulsants caused the extent of their bioavailability, binding to plasma proteins (clinical effect has a free fraction of drug penetrating the blood-brain barrier), the interaction with the enzyme systems of liver, half-life. Linking Finlepsina to plasma proteins is carried out at 75%, the active fraction of the drug is 25%. Extensively bound to proteins valproate (90%) and at the level of plasma concentrations below 45-50 mg / ml did not allow for the saturation effect of the active fractions in the scene. Peak serum concentrations after oral administration Finlepsina achieved after 4-10 hours, Konvulsofina - after 1-4 hours, which allows to use the drug for acute mania. Therapeutic range timoizolepticheskogo steps to Finlepsina is 400-600 mg for Konvulsofina - 600-1000 mg. Side effects of anticonvulsants can be divided into two groups: the idiosyncratic (dozonezavisimye) and relatively predictable (dose-related), arising from the introduction of excessively high doses of a drug or use it for too long time.