The method is used in primary care ...

Method is used in general practice in the event that attacks the disease (migraine, angina, asthma) are provoked by psychogenic aspects. We have briefly described just some of the commonly used and generally accepted methods of psychotherapy used in the treatment of somatic diseases. Those who would like to learn more about them, as well as many other psychotherapeutic techniques, please refer to the specialized manuals for psychotherapy and psychosomatic medicine. The task of this article - to attract the attention of doctors to the field of medical knowledge, has not yet found significant practical use in our country. The article was published in the magazine's doctor

treatment of depression non-psychotic level: the experience of Pirazidola - efficacy and safety

Professor EB Dubnik, MD BA Volel Mental Health Research Center RAMS, Moscow Introduction Clinical experience has confirmed the severity and potential risk of side effects of traditional monoamine oxidase inhibitors (hepatotoxicity, potentiation of pressor effects of tyramine), coupled with a long, growing to the extent reception or irreversible inhibition of enzymatic activity, required denial of the widespread use of of this series. However, in further pharmacological studies could not account for the fact that the inhibition of monoamine oxidase - a specific enzyme that catalyzes the oxidative deamination of monoamines involved in regulating the functions of the CNS, is one of the most important routes of exposure to the neurotransmitter processes which determine the basic mechanisms of depression. Data on the multiplicity of monoamine oxidase with the release of two types: MAO-A and MAO-B will help to focus scientific inquiry in the field of psychopharmacology of antidepressants on the synthesis of compounds like inhibitors block the enzyme and causing the cumulation of monoamine neurotransmitters, but devoid of undesirable effects of conventional MAOIs. Development of research in this direction has led to the synthesis of MAOIs selective action (OIMAO-A), depressing the enzyme for a short time and, accordingly - obviously with minimal side effects inherent in the MAOI. Among the antidepressant drugs with such properties is pirlindol (Pirazidol) - one of the first representatives OIMAO-A. As an atypical antidepressant chetyrehtsiklicheskoy structure synthesized by domestic Neuropharmacology back in 1975, and the most active among the compounds of this series, Pirazidol found an original mechanism of action: an inhibitory effect not only on the activity of MAO, but also on neuronal capture of monoamines. Along with the selective inhibition of MAO type A Pirazidol selectively deaminated serotonin and noradrenaline. Active pharmacological and clinical studies OIMAO-A and in particular, pirlindola, held from the late 70's, has confirmed it is comparable with the action of tricyclics antidepressant activity, and an advantage over TCAs in terms of lack of cardiotoxic and anticholinergic side effects [1,2,5,6 , 21].