Dementia of vascular origin ...

In dementia of vascular origin is a violation of the cerebral blood flow. In conditions of hypoxia in brain tissue increases the formation and accumulation of unoxidized metabolic products (lactate), and as a result of developing acidosis. Due to acidification of the medium is disturbed activity of various susceptible to pH levels of enzymes and loses the ability of cells to glucose utilization in normal quantities. Experimental studies have shown that gemodializat able to change this non-winning situation in a positive way. It was found that Actovegin stimulates utilization of oxygen by liver cells, in particular, the mitochondria of hepatocytes. It was also revealed increased production of energy-phosphates, especially ATP, not only in the mitochondria of liver cells but also cells of the brain. This effect is dose dependent. Its effects on the exchange of oxygen in the mitochondria, gemodializat has protective properties under conditions of hypoxia, which was shown in experiments with recording of electroencephalograms (EEG). In conditions of low oxygen partial pressure, which can be observed at an altitude of 12,000 feet above sea level, also demonstrated the protective properties of Actovegin intravenous, peritoneal and oral administration. Comparable effect was observed on a model of ischemic stroke. In this study achieved complete 15-minute ischemia, followed by postischemic recirculation. Compared with the control group in the cerebral cortex, hippocampus and cerebellum of rats treated with Actovegin, we observed significantly higher levels of ATP and phosphocreatine. In subsequent clinical studies have proved the protective effect of Actovegin on metabolism of the brain. In healthy probands carried out psychometric and electroencephalographic (EEG) examination. It was shown that treatment with Actovegin greatly reduces the negative effect of barbiturate anesthesia on brain activity. In patients with cerebrovascular disorders, as well as in healthy volunteers, under the influence of therapy Actovegin increases cerebral blood flow. The positive effect of oral Actovegin on cognitive function has been confirmed by clinical studies using EEG and psychometric tests. Particularly marked improvements were observed in parietal, fronto-central and occipital areas, which indicates an improvement in cognitive functions. Studies of P-300-amplitudes in the central and parietal brain regions were also able to show improvement in information processing. Materials and methods One study [1] was to answer the question of whether a three-month therapy gemodializatom in his oral (versus placebo) to improve clinical symptoms and cognitive function in patients with mild to moderate dementia. This placebo-controlled, randomized, double-blind study consisted of a four-week preparatory and dvenadtsatinedelnoy main phases.