Currently verified the effectiveness of hormone replacement therapy in the treatment of fully developed Alzheimer's disease, carried out extensive studies of older women undergoing hormone replacement therapy, including those in the outcome of treatment was found to decrease mental abilities. Thus, it is too early to talk about improving the mental processes as a potential effect of HRT, along with prevention of osteoporosis and cardiovascular disease. Smoking - undoubtedly a risk factor when it comes to development of several diseases in the elderly, including cancer and atherosclerosis. The latter increases the risk of vascular dementia and cognitive decline in old age due to increased atherosclerosis and worsening hemodynamics. However, some studies indicate a possible reduction in the risk of Alzheimer's disease from smoking in old age. A small number of clinical trials on the use of nicotine or its agonists also confirm the positive effect of nicotine on the treatment of Alzheimer's disease and allow us to consider smoking as a protective factor for dementia. During large-scale study known as Gonolulskoy heart of the program [9], which swept through 3,429 Japanese and Americans, was established positive correlation between smoking in middle age and risk of cognitive decline in elderly. In this group, beneficial effects on mental processes has had a long-term abstinence from smoking. Nutrition Pathological mechanisms of Alzheimer's disease may involve oxidative stress and accumulation of free radicals, which in turn can lead to excessive lipid peroxidation, violation of the integrity of neuronal membranes and the gradual death of brain cells. The study of nutritional factors found an association between diet and decreased mental ability in old age. In this case, under investigation were so-called "food diary", in addition, they measured the concentration of micronutrients in the blood. Factors such as poverty and smoking, are associated with increased risk of stroke - perhaps this explains the activation of brain aging and destruction of endothelial membranes. Since cerebrovascular disease is associated increased risk of stroke and vascular dementia. With the help of a diet can prevent these diseases, although, of course, often difficult to separate the "healthy eating" from the "healthy lifestyle". Whatever it was, the fact that different studies (food diary, and changes in the concentration of substances in the plasma) led largely to the same conclusions, saying the important role of diet in the prevention of deterioration of mental processes and possibly dementia. B. Gilman et al found that, taking into account features of lifestyle consumption of fruits and vegetables reduced the risk of stroke. Similarly, R. Gale and colleagues studied the relationship between cause of death, cognitive function in old age and certain conditions of life, including diet. They concluded that vascular disease of the brain are not the ultimate cause of mental disorders in old age and the use of vitamin C can protect and from mental disorders, and cerebrovascular disorders. "
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