Concentration of antioxidants in blood plasma in many ways to predict the preservation of cognitive function in old age. This is illustrated by a 22-year study of patients' lifestyles. Eating vitamin C and beta-carotene contained in fruits and vegetables, and alpha-tocopherol (vitamin E) affected the ability to perform cognitive tests in old age. Active use of dietary polyunsaturated fatty acids (such as linoleic acid) or insufficient intake of antioxidants can cause oxidative stress and cause predisposition to atherosclerosis. In the study, patients older group, held in the period from 1990 to 1993 and engulfed the 390 people are elderly, it was shown that these factors increase the risk of reduced mental abilities. In addition, an association between higher consumption of linoleic acid and decreased mental ability. Found an inverse relationship between fish consumption and decreased mental ability, when it is proved that antioxidants (vitamins A, C and E) do not have any protective effect with respect to cognitive function. Another epidemiological study involving 137 elderly people, has allowed more time to confirm the role of diet in the prevention of cognitive impairment in old age, but were not given the same micronutrients. High consumption in the past of vitamins A, C and E was associated with better performance of specific neurophysiological tests. There is also evidence of a randomized trial, during which we studied the effect of vitamin E supplementation (2000 IU / day) for treatment of Alzheimer's disease. Before treatment between control and experimental groups, there were no differences, but the rate of vitamin E was enough to slow the progression of dementia by an average of eight months. Nonsteroidal anti-inflammatory drugs The relationship between cerebrovascular disease and decreased mental abilities, so it is expedient to use aspirin for the prevention of dementia. Antiaggregatory properties of aspirin prevent transient ischemic attacks and thrombosis, influencing the mechanisms involved in the prevention of vascular dementia. The project is the protection of health of the elderly in East Boston study was conducted that engulfed 3,809 people. It is possible to prove that the appointment of aspirin comes some improvement in cognitive function. It was suggested that if aspirin is used in higher doses of anti-inflammatory, but not in low antithrombotics, the effect of this drug to improve cognitive function increases. Epidemiological studies indicate that chronic use of nonsteroidal anti-inflammatory drugs reduces the risk of cognitive decline in old age. According to a clinical trial, indomethacin improves short-term memory in healthy older people.
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