Three patients with psychotic depression ...

These properties make the antidepressant Paxil very promising, but its use in the treatment of mixed affective, disorder, endogenous depression aggravated by organically deficient background, panic attacks developed on the basis of true dientsefalnyh crises with the formation of ipohondricheskrgo studied enough. Indirect influence of Paxil to additional psychopathology products also remains a matter of debate. The above has led us to attempt a differential analysis of the features psychotropic Pax, communication between the individual components of its antidepressant activity and clinical and pathological structure of the complex depressive syndrome. On the Republican Psychiatric Hospital MOH, we used Paxil in a dose of 20 mg. per day to 60 mg. daily as monotherapy and in combination with neuroleptics, and cerebroprotector vazotropnymi drugs for relief of depressive symptoms in four women. Three patients with psychotic depression were treated with the register permanently, one with a neurotic level depression continued maintenance therapy paksilom 20 mg. a day 2 months as outpatients. The duration of treatment paksilom not limited and determined by clinical evidence. Treatment efficacy was assessed comprehensively before treatment, after 5 days and at the end of the course. With the scale of the Hamilton Depression and Anxiety (HAMD, HAMA) Depression Scale Montgomery - Asberg (MARDS), questionnaire, Beck Depression Inventory (BDI) analyzed the psycho-dynamic parameters of the patients. The dynamics of suicidal behavior was assessed in points: the idea of ??inferiority of life - 1 point, suicidal planning - 2 points, active suicidal ideation - 3 points, suicidal actions - 4 points. This article analyzes some of the psychotropic aktivnosi Paxil for example, three patients with psychotic depression, according to its clinicopathological features. Before therapy paksilom in A., B., B., patients on a scale HAMD diagnosed "major depressive episode" (36, 41 and 42 points respectively), for MADRS - "clinically significant depression (35, 32 and 49 points respectively ). BDI questionnaire revealed the presence of "severe depression" (A. - 35, B. - 47, VA - 56 points). Initially, rates of anxiety and 24-item scale, HAMA korilirovali with the assessment of depressive scales, respectively, the depth of affective disorders (above 30 points). Side effects of the drug were recorded by SARS. Mean values ??on the scale for all patients, except for V., maximum doses do not exceed 1.3 points. Pronounced fluctuations in vascular tone have been reported with significant organic pathology with decreased blood flow in carotid vascular system (the conclusion of patient V. REG). They are easily korrgirovalis when you cancel the appointment of Paxil and heart analeptics. In other cases, undesirable side effects were mild and transient in the presence of patients with age and somatic features.