Representatives of the antidepressant-sedatikov ...

Representatives of the antidepressant-sedatikov are amitriptyline trimipramin (syurmontil, gerfonal), doxepin (sinekvan). They have a high timoanalepticheskim which combines with a strong sedative and antitrevozhnym. Such a spectrum of antidepressant activity allows their use in different types of endogenous depressions varying severity. But especially these drugs are shown in anxiety and agitated depression, including sleep disorders. They do not cause exacerbation of psychotic symptoms, are assigned 2-3 times a day and also at night. Tricyclic antidepressants, stimulants - imipramine (Melipraminum) dibenzepin (Nover), desipramine (pertofran, petilil), clomipramine (anafranil, gidifen) - have the ability to eliminate the vital depressive affect and enhance inhibited ideatornoy and motor activity. At the same time, they can exacerbate the manifestations of anxiety, delusions and hallucinations enhance or induce sleep. Therefore, the main indication for their intended purpose are of different depths classic melancholic depression and lethargy. The above-mentioned drugs are recommended for use only twice a day (morning and afternoon) and not appointed by the evening and at night. Side effects of tricyclic antidepressants caused cholinolytic effect of exposure on the autonomic nervous system. These psychotropic drugs often complicate the treatment of endogenous depression, leading to its abolition. Tricyclic antidepressant compounds are antidepressants I generation, but amitriptyline and imipramine are used so far as reference for comparative study of psychotropic activity of new groups of antidepressants. Monoamine oxidase inhibitors (MAOIs) are also anti-depressants I generation, but are now being used is limited, since, having no advantages in strength timoanalepticheskoy activity before tricyclic antidepressants, stimulants, they possess a pronounced toxicity (with a toxic effect on the liver) and the property cause an incompatibility reaction with a number of drugs (ephedrine, epinephrine, mezaton, morphine, reserpine) and food (cheese, tomatoes, beans, meats, meat, yeast, herring, cream, beer, wine) until death. Most widely used in psychiatry have Nialamide (nuredal) indopan, traniltsipronil (transamin), phenelzine (Nardil). In the spectrum of psychotropic activity timoanaleptichesky effect introduced sparingly and combined with a strong stimulant. The main indications for appointment may be inhibited and the adynamic depression, including those resistant to other forms of antidepressant therapy. They lead to an exacerbation of psychotic symptoms. Unacceptable combination of MAOIs with each other, with tricyclic and tetracyclic antidepressants with stimulants. In the transition to therapy incompatible drugs before and after the appointment of MAOIs required treatment interruption for at least two weeks.