From "atypical" antidepressants ...

From the "atypical" antidepressants II generation to practice became widespread maprotiline (ludiomil) and viloksazin (vivalan, emovit), Mianserin (miansan, lerivon, tolvon), trazodone (trandin) , nomifenzin (Aliwal) opipramol (insidon, pramolan), domestic and pirazidol inkazan. Among antidepressants II generation in the subsequent widespread practice group received the antidepressant MAOI short-acting, non-selective (inkazan) or selectively blocking the monoamine oxidase type A (pirazidol, befol, karaksazon, moclobemide or auroriks). Typical properties for their mechanism of action is enhancement of serotonin and dopamine in the brain, blockade, like the TSA, the reuptake of norepinephrine and to a lesser extent - serotonin. Being reversible MAOIs, they are more safe when used as a antidepressants. In the spectrum of antidepressant activity of drugs moderate timoanalepticheskoe action combined with a strong activating and sedating than shown. The advantage of MAOI type A is the possibility of long-term use in the outpatient setting. They are small and antidepressants are most effective in shallow endogenous depression with atypical pattern and phenomena adynamia, anesthetic and asthenic symptoms. In the following, among the "small" antidepressant recognition of psychiatrists received tricyclic compounds tianeptine (coaxil, stablon). Unlike other drugs antiserotoninergicheskih it facilitates the reuptake of serotonin and does not noradrenergic and dopaminergic actions. timolepticheskim drug has a moderate and more pronounced anxiolytic effect, restores the disturbed sleep that causes the main indications for its administration at a shallow level of endogenous depression with somatovegetative, senesto algicheskimi-and anxiety-phobic disorders, and allows us to recommend taking it to 3-4 times a day, including in the evening, as well as in outpatient settings. Further search for effective antidepressant funds went towards the development of compounds that possess the property of selectivity neurochemical actions. So, with 80 years of XX century was the spread of a group of antidepressants, which united the property of selective serotonin effects on the exchange almost without affecting the noradrenergic processes. They are called selective serotonin reuptake inhibitors (SSRI-drugs), are indicated as well as antidepressants III generation. neurochemical mechanisms of clinical action of this group of drugs have non-selective involvement of different types of serotonin receptors. In accordance with receptor theory of the formation of depressions they cause features of serotonergic drugs. Impact on 5-HT 1 receptor ensures proper timoanalepticheskoe and protivotrevozhnoe action of these drugs, and stimulation 5NT2 5NT3 and determines the presence and nature of their side effects.