Protective actions (rituals) in ...

Protective actions (rituals) of persons surveyed were in the nature of so-called direct protection (NM Asatiani), which is reflected in the fact that patients wanted to avoid medical treatment. Some people involved in its protective actions relatives: relatives came to doctors asking them not to prescribe, they brought the whole list of drugs that are "not tolerate" the patient, supporting patients in their rejection of pharmacotherapy. Taken together, this led to a worsening of the flow as mental and somatic diseases. According to the literature [3], in recent years, the increased frequency of severe anaphylactic and toxic-allergic reactions to pharmacological agents. Therefore, a careful clinical and allergy screening of all patients for farmakofobii to identify the nature of drug intolerance. In this case, the main task was the selection of true allergic reactions, the differential diagnosis between them and pseudo reactions to medications, as well as the selection of drugs that do not cause allergy in this patient (psychotropic drugs, antibiotics, anesthetics, analgesics, etc.) for the diagnosis of drug allergy were used Data allergy and pharmacological analysis. Major role in the specific diagnosis of true allergic reaction is a natural test of inhibition of emigration of leukocytes (TTEEL) in vivo under the influence of the drug. The next stage of the survey were allergic provocation tests with drugs, carried out only in case of a negative TTEEL. Widely used tests with a placebo (saline), a value which is very valuable for both diagnosis (some patients were given "positive" reaction to placebo) and for psychological adjustment, as after a negative provocation test with placebo, patients were transferred to safer with this survey drug. As a result of the activities are allergic to medicines has been identified only in 15 out of 56 patients. The incidence of allergic reactions dominated antibiotics and nonsteroidal anti-inflammatory drugs. In the remaining cases were non-allergic reactions, which were distributed as follows: reactions due to side effects of drugs - in eight patients toxic effects caused by overdosing on pharmacological and / or polypharmacy - in four cases, drug intolerance, associated with the violation of the metabolism of drugs due to diseases of the gastrointestinal tract and liver - in 10 persons surveyed, psychogenic reaction to the medication - in 19 patients. The main causes of reactions to drugs in the structure of drug intolerance in patients with farmakofobiey shown in Fig. 1. Reasons for responses to pharmacological agents are diverse, including allergic reactions were detected only in 15 patients. The largest group - 19 - were psychogenic reaction.