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Points to link the duration of the initial period of the disease without treatment, followed by periods of formation, as well as complete remission therapy [13]. Draws attention to the "biological toxicity" long untreated psychotic state at the manifestation of the disease. First mooted severe mental illness (first psychotic episode of illness) is a severe biological and social stress for the patient and his relatives. In this case, as has been shown in several studies, early detection and treatment of first psychotic state leads to minimization of psychosocial stress and the negative impact of the disease, contributes to a more favorable course and social recovery of patients. With these data in many countries (Australia, Canada, Finland, etc.) are clinic first psychotic episode. Such a clinic in November 2000 in a Moscow Institute of Psychiatry, Ministry of Health of the Russian Federation. In the near future the organization of similar clinics in mental health services of several other regions of Russia. Contingent, which is assisting in the clinic of the first psychotic episode are patients with schizophrenia or schizophrenia spectrum disorders with a duration zabolevaniyane more than five years after the demonstration, during which mentioned no more than 3 psychotic episodes. Preference is given to the form of semi-stationary and ambulatory care patients, since data show that 60% of patients with first psychotic episode can live without hospitalization. The remaining patients after relief of acute manifestations of psychosis in a patient can be transferred to the specified clinic. Tactics to assist in the department of first psychotic episode should include a number of points. 1. In the clinic are sent to all patients with first episode of a particular service area. 2. Work on possible early detection of primary psychopathological disorders, especially among those seeking a primary care network, and the inclusion of the identified patient assistance program (time reduction "untreated psychosis"). 3. Assistance is provided in the least stigmatizing conditions (semi-stationary, outpatient treatment) based on the principle of partnership with the patient. 4. Clinic of the first episode of the disease works on the basis of Brigadier Multiprofessional (involving a psychiatrist, psychologist, therapist, social worker) of the patients. 5. Performed the best choice neuroleptic therapy with the preferred use of the new generation antipsychotics (atypical antipsychotics). 6. Used an early accession of psychosocial interventions: the inclusion of patients and their relatives in psihoobrazovatelnye program, exercise training, social skills and neurocognitive training. 7. Planned follow-up management of patients within 5 years after onset. Early detection of psychopathologic disorders before the first symptomatic episode of a subset of patients indicated a fairly long period of illness at different levels, celebrated prior to seeking psychiatric help.