Tactically, medical devices include ...

Tactically, medical devices also include a change of medication, intermittent reception, reducing the dose. Drug interaction benzodiazepines Given the forced polypharmacy in elderly patients with multiple somatic pathology inevitably arises the problem of drug interactions, in particular, the interaction of benzodiazepine drugs with other drugs in the combined appointing them seniors and the elderly: increased hypotensive effect of clonidine, ACE inhibitors, the risk of high blood pressure during simultaneous introduction teofillinovyh drugs; depressing effect on the CNS in the combined use of b-blockers, increase the concentration of sedative (midazolam) in serum at sochetnnom application with calcium channel blockers, increase the concentration of cardiac glycosides in serum, when combined with cimetidine, omeprazole increases the concentration of benzodiazepines in serum, when taking anticoagulants (warfarin), there is some increase in prothrombin time, increased hypoglycemic effect, while the application of antidiabetic drugs, macrolides, slow metabolism alprazolam, in contrast, rifampicin, according to some, has the ability to accelerate the metabolism of diazepam. Isoniazid inhibits the metabolism of diazepam. Side effects of benzodiazepines, the issue of side effects of treatment of sleep disorders benzodiazepine derivatives, such of them as muscle relaxation and trace drowsiness, well known to doctors (usually skipped and the main contraindication - diagnosed with myasthenia gravis or myasthenic syndrome). As experience shows, the emergence of adverse effects makes the patients themselves with intact criticism to stop taking drugs to lower the dose, slowed to receive or to resort to alternative methods of treating sleep disorders. Less awareness of general practitioners typically have the modest inhibitory action on the respiratory center, especially in chronic obstructive pulmonary disease, may cause constipation while taking clonazepam, a benzodiazepine bromdigidrohlorfenil. One should also bear in mind the possibility of reducing myocardial contractile function, diffuse arterial hypotension. Adverse effects of tranquilizers, hypnotics in patients with middle and old age: excessive sedation, muscle relaxation, imbalance, falls, disturbances of concentration; worsening dismnesticheskih disorders. In general, the use of benzodiazepines for sleep disorders in the elderly and the elderly is safe enough, and it is well known to practitioners. Drug dependent natural concern both doctors and patients themselves are causing the problem of drug addiction. Is not ignoring this problem, we should recognize that, in its pronounced clinical manifestations, that is, with the development of psychic and physical dependence, signs of increasing tolerance, the need for increasing doses and severe manifestations of withdrawal syndrome is observed in the elderly and the elderly are rare.