Statistical analysis was carried out ...

Statistical analysis was performed using methods of nonparametric statistics. The results fully completed the study 29 out of 30 patients, representing 96.6% of the patients studied sample size (reason for therapy discontinuation in this case is a patient admitted violation of the treatment regimen).. The positive effect of treatment (expressed and significant improvement on the scale of CGI) recorded in most patients: the total efficiency was 73% (Fig. 1). It should be noted that the proportion of responders in the sample is comparable with the calculations, driven by both domestic and foreign authors [3,7,16,18]. Fig. 1 . The overall efficiency and frequency of adverse events on therapy pirazidolom in the sample (n = 29) Data on the good tolerability and safety Pirazidola cited in the literature [10,13,17,19], also agrees with the results obtained in this study. accompanying therapy side effects, as shown in Figure 1, revealed approximately a quarter of patients (8 of 29 patients - 27,6%). Moreover, all adverse events: dry mouth (3 cases), tachycardia (2 cases), sweating (2 cases), dizziness (1 case) - were among the lungs, not only do not require therapy discontinuation, even reduction of the dose due to their complete reversibility within a few days. anticholinergic nature of side effects allows you to associate them with exposure to Pirazidola not so much a system of inhibition of MAO, but rather on the reuptake of monoamines, inherent in this antidepressant [6,8]. The positive dynamics with reduction of depressive disorders in the process of therapy (weekly decrease in the average summary scores on the Hamilton scale) are graphically represented in Figure 2. You can see that in During the treatment there is a harmonious reduction manifestations of depression. The tendency to reduce the amount of points on this scale is clearly revealed by the second week of therapy and to the 4 th week of more than 50% reduction in the values ??of the relevant parameters are statistically significant (rDepressii in later life

H . Mikhailova concept of late-life depression is used to indicate disease states, first developing in the period of aging. But, in addition, this term reflects a distinct age-depressive manifestations in both cases, the initial onset of depression in later life, and at relapse of the disease many years ago . Depressive disorders consistently ranks first in frequency among mental disorders in elderly and senile age. Depression occur at any age period of aging, but the largest vulnerability to depression is noted in old age (60-75 years). The women in this age group is three times more likely to exhibit symptoms of depression than men. In old age (75-90 years), this difference in the incidence of depression in men and women are falling sverhpozdnem age (after 90 years) almost disappears. Among the Elderly Depression in general are much rarer.