Materials and methods The study ...

Materials and methods The study included patients of middle age with coronary artery disease and depression. Excluded from the study, patients with delirium, dementia, amnestic and other cognitive disorders, substance abuse; schizophrenia and other psychotic disorders, posttraumatic stressful disorders, acute stressful illness, thyroid disease, diabetes, liver failure, severe and not amenable to correction liver, kidney, pulmonary, neurological, metabolic diseases, or cancer at the time of the study or within 6 months before the study. Verification of IHD based on characteristic clinical, verifiable history of myocardial infarction, the data of daily monitoring of ECG, stress tests and some of the patients on the results of coronary angiography. Depression were diagnosed on the basis of previously described clinical criteria developed by the department staff to study the pathology of borderline mental and psychosomatic disorders SCMH RAMS [16]. Effectiveness Pirazidola (primary endpoints) to verify statistically significant reduction in total score 17-item Hamilton Depression Scale (SdH). To assess the significance of differences using the nonparametric Wilcoxon test. Statistical analysis was performed using the software Statistica for Windows (StatSoft, Inc. 1984-1995). Recorded the clinical signs of reduction of affective disorders. Safety of study drug was assessed by the number of adverse events. In this case, using data from a routine cardiac examination, which included daily monitoring of blood pressure and heart rate, ECG (before treatment and in the future - weekly), orthostatic (weekly) (orthostatic hypotension was fixed when the difference between the blood pressure in supine and standing positions was 30 or more mm Hg). Any deviation from the expected vozdeystvmya cardiotropic therapy were considered as a possible result of interactions of drugs used in the treatment of cardiovascular disease, and Pirazidola. The drug was administered for 28 days as follows: initial dose - 50 mg, maximum - 300 mg in 2 daily admission, which was achieved (if necessary) not earlier than 6 days of treatment. Patients The sample consisted of 30 patients aged from 21 to 65 years (19 men, 11 women), of whom 17 patients were hospitalized in the cardiology clinic MMA behalf IM Medical Academy, another 13 - a branch of cardiac surgery (elective surgery for CABG), Russian Research Center of Surgery RAMS. Median total score SdH - 17 points, 13-19 percentiles. Dominated by patients with postinfarction cardiosclerosis (20 cases). In 19 patients had angina high (III-IV) functional classes. In 21 of the 30 patients identified nozogennye depression (depressive reaction to a combination of stressful factors associated with awareness of the dangers of the disease, risks associated with its methods of treatment, changes in quality of life, etc. [13,14]), has a 9 - dysthymia [15].