Tranquilizers Tranquilizers ...

Tranquilizers Tranquilizers are widely used not only in mental health, but the actual midwifery practice. They can easily pass through the placental barrier. After intravenous injection of diazepam women in childbirth, he is found in fetal blood after 5 minutes, with a concentration higher than in maternal blood [1]. This can lead to accumulation of drug in the blood of the fetus. In addition, newborns increased as compared with adults elimination half of the drug, and its significant amount can be determined in the blood for a long time after birth. Revealed that the application of diazepam in the first trimester of pregnancy increases the risk of neonatal cleft palate, upper lip and the development of inguinal hernia [16,17]. Long-term use of the drug during pregnancy can lead to its accumulation in fetal tissues (particularly in adipose tissue and liver) and condition thereby toxic effects. Newborns can be marked muscular hypotonia, hypothermia, hyperbilirubinemia [6]. Possible respiratory depression until it stops and violations of the sucking reflex [1,3]. The use of diazepam in low doses during childbirth, as a rule, does not provide kakogolibo adverse effects on the fetus, but high doses can lead to seizures in newborn asphyxia, reduced muscle tone, abnormal metabolic responses to temperature decrease. The possibility of toxic effects of diazepam (and other tranquilizers) in the fetus and the newborn makes cautious to recommend its use during pregnancy, although in most cases to identify kakielibo functional impairment in excess of the level found in children whose mothers did not take diazepam, failed. This is probably due to the short duration and relatively low doses of the drug used. When using antidepressants tricyclic antidepressants may increase the likelihood of congenital skeletal anomalies, mainly limb malformations [10]. However, these data do not appear until the end unconvincing. Apparently, this group of drugs has a relatively low teratogenic, at least in nizkihsrednih doses and at later stages of pregnancy. The use of ultrahigh doses leads to multiple severe congenital malformations in the fetus. When using tricyclic antidepressants in late pregnancy may experience neonatal functional impairment related to, inter alia, cholinolytic action of drugs: urinary retention, tachycardia, respiratory disorders, peripheral cyanosis, increased muscle tone, tremors, clonic jerks [6.15]. The risk of using drugs during pregnancy, a new generation, and, in particular serotonin reuptake inhibitors, has been studied enough. There is also evidence of the absence in these cases expressed malformations in children [9], although reports of the possibility of them not sharply marked pathology in the postpartum period [4.13].