Such therapy can very quickly cut short depression, despite rising while the risk of collateral (such as neurotrophic and somatotropic) actions, as well as adverse interactions with STH means. Antidepressants are highlighted in this series (amitriptyline, imipramine, clomipramine), MAO inhibitors should be used with great caution. In somatic patients, especially in elderly and senile patients, their use carries a risk of confusion (delirious state, occurring with impairment of consciousness, disorientation in time, space and its own state, changes in sleep cycle - waking, disorders of attention and memory, flash psychomotor agitation, illusory, hallucinatory phenomena). The signs of confusion is possible with parenteral administration of other drugs of this series, such as benzodiazepine derivatives (diazepam, etc). Likelihood of confusion is greatly increased in individuals who abuse alcohol and drugs, as well as during combination therapy, including both psychotropic and somatotropic some means (AV Medvedev, 1999). The importance of early recognition of the state of confusion. When an erroneous diagnosis is often confused attempts to relieve symptoms of psychomotor agitation and hallucinatory disorders by forcing psychotropic effects (increasing doses of psychopharmacological drugs, etc.), which is fraught with significant worsening of the condition. Manifestation of even short-term (often nocturnal) episodes of confusion - a testimony to the complete cessation (when appropriate detoxification activities) or to modify psychopharmacological therapy (dose reduction, treatment of first-line drugs). You should also remember that in the primary care network should be given a minimum of psychotropic drugs (1-2 drugs). This is due to their possible interactions are not always well-known general practitioner, as well as the chance of side effects. Single or double dose of medication that does not destroy significantly the daily routine of patients and preventing professional activities, the most expedient in the hospitals of the general type, and especially in the outpatient setting. Effectiveness of therapy depends not only on the properties of the drug, but also on the way to its introduction, dose, regimen, and such seemingly less obvious factors as the ratio of the patient and his relatives to the treatment. The choice of antidepressants depends on factors such as age, somatic condition of the patient, and tolerance (the individual sensitivity) to psychotropic drugs. Must also take into account past experience of the patient (for episodes of mental disorders in history) and information about the features of the reaction to the therapy of his close relatives if they were treated with psychotropic drugs.
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